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SR-4835
CAS No. 2387704-62-1
SR-4835( —— )
Catalog No. M21578 CAS No. 2387704-62-1
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 126 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 282 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 546 | In Stock |
|
| 200MG | 758 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSR-4835
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NoteResearch use only, not for human use.
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Brief DescriptionSR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
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DescriptionSR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
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In VitroWestern Blot Analysis Cell Line:MDA-MB-231 cells Concentration:90 nM Incubation Time:0.5, 6, 24, 48 hours Result:Suppressed ATM and RAD51 protein levels.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number2387704-62-1
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Formula Weight499.36
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Molecular FormulaC21H20Cl2N10O
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Purity>98% (HPLC)
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SolubilityDMSO:5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60°C)
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SMILESCn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Quereda V et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6.
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