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L-(+)-Ergothioneine

CAS No. 497-30-3

L-(+)-Ergothioneine( Ergothioneine )

Catalog No. M21510 CAS No. 497-30-3

Ergothioneine is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-(+)-Ergothioneine
  • Note
    Research use only, not for human use.
  • Brief Description
    Ergothioneine is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.
  • Description
    Ergothioneine is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.
  • In Vitro
    Cell Viability Assay Cell Line:PC12 Concentration:0.25, 1 mM Incubation Time:23 h Result:Increased cell viability by approximately 13% and 34%, respectively.Western Blot Analysis Cell Line:PC12 Concentration:0.25, 1 mM Incubation Time:23 h Result:Counteracted the p38 phosphorylation induced by 1 h incubation with H2O2.
  • In Vivo
    Animal Model:Cisplatin-treated ratsDosage:70 mg/kg Administration:p.o.Result:Decreased serum creatinine and BUN.Increased GFR at two-fold.Suppressed cisplatin-induced oxidative stress and GCT.Up-regulated the levels of Nrf2, NQO1, and HO-1. Suppresses NF-κB signaling and the pro-inflammatory cytokines.
  • Synonyms
    Ergothioneine
  • Pathway
    Others
  • Target
    Antioxidant
  • Recptor
    Antioxidant
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    497-30-3
  • Formula Weight
    229.3
  • Molecular Formula
    C9H15N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:125 mg/mL (545.14 mM; Need ultrasonic)
  • SMILES
    C[N+](C)(C)[C@@H](Cc1c[nH]c(=S)[nH]1)C([O-])=O
  • Chemical Name
    (S)-3-(2-thioxo-23-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Oumari M et al. Regeneration of ergothioneine after reaction with singlet oxygen. Free Radic Biol Med. 2019 Apr;134:498-504.
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