5'-Methylthioadenosine( Methylthioadenosine | 5'-(Methylthio)-5'-deoxyadenosine | 5'-Deoxy-5'-(methylthio)adenosine | 5'-S-Methyl-5'-thioadenosine )

Catalog No. M21415 CAS No. 2457-80-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

5'-Methylthioadenosine
Note

Research use only, not for human use.
Brief Description

5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
Description

5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
In Vitro

Cell Viability Assay Cell Line:MTAP+ and MTAP? NIH3T3 cells, isogenic MTAP+ and MTAP? cell line derived from a human HT1080 fibrosarcoma cell line Concentration:6TG and 2FA in combination with 10 μM MTA Incubation Time:48 hours Result:Significantly increased IC50 concentration in MTAP+ cells, but no significant change in MTAP? cells.
In Vivo

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Synonyms

Methylthioadenosine | 5'-(Methylthio)-5'-deoxyadenosine | 5'-Deoxy-5'-(methylthio)adenosine | 5'-S-Methyl-5'-thioadenosine
Pathway

Proteasome/Ubiquitin
Target

Endogenous Metabolite
Recptor

Human Endogenous Metabolite
Research Area

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Indication

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CAS Number

2457-80-9
Formula Weight

297.33
Molecular Formula

C11H15N5O3S
Purity

>98% (HPLC)
Solubility

DMSO:5 mg/mL (168.16 mM);DMF:2.5 mg/mL (8.41 mM);H2O:1 mg/mL (3.36 mM)
SMILES

CSC[C@H]([C@H]([C@H]1O)O)O[C@H]1n1c2ncnc(N)c2nc1
Chemical Name

(2R3R4S5S)-2-(6-amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-34-diol

1.Avila MA et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30.

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