BTZO-1

CAS No. 99420-15-2

BTZO-1( —— )

Catalog No. M21169 CAS No. 99420-15-2

BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 51 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 78 In Stock
25MG 157 In Stock
50MG 230 In Stock
100MG 342 In Stock
200MG 486 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    BTZO-1
  • Note
    Research use only, not for human use.
  • Brief Description
    BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
  • Description
    BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
  • In Vitro
    BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5),the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM.BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes.Cell Viability Assay Cell Line:Primary Neonatal Rat Cardiomyocytes Concentration:0-330 nM Incubation Time:24 hours Result:Suppressed serum deprivation or DOX-induced cell death.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99420-15-2
  • Formula Weight
    240.29
  • Molecular Formula
    C13H8N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:8.33 mg/mL (34.67 mM; Need ultrasonic)
  • SMILES
    O=c1nc(-c2ccccn2)sc2ccccc12
  • Chemical Name
    2-Pyridin-2-yl-13-benzothiazin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kimura H Sato Y Tajima Y et al. BTZO-1 a Cardioprotective Agent Reveals that Macrophage Migration Inhibitory Factor Regulates ARE-Mediated Gene Expression[J]. Chemistry & Biology 2010 17(12):1282-1294.
molnova catalog
related products
  • Methyl-4-oxoretinoat...

    Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other skin disorders.Methyl-4-oxoretinoate has the potential to be used in the treatment of a variety of ocular disorders such as age-related macular degeneration. related macular degeneration).

  • 1-beta-D-Arabinofura...

    1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.

  • 3-O-Methylgallic aci...

    3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation in the gut. 3,4-Dihydroxy-5-methoxybenzoic acid inhibits transcription factors NF-κB, AP-1, STAT-1, and OCT-1 which are known to be activated in colorectal cancer.