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PBD-150
CAS No. 790663-33-1
PBD-150( —— )
Catalog No. M21163 CAS No. 790663-33-1
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 86 | In Stock |
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| 25MG | 174 | In Stock |
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| 50MG | 253 | In Stock |
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| 100MG | 377 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePBD-150
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NoteResearch use only, not for human use.
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Brief DescriptionPBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM).
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DescriptionPBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM).
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In Vitro——
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In VivoPBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetBeta Amyloid
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Recptorglutaminyl cyclase (hQC) Y115E-Y117E
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Research Area——
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Indication——
Chemical Information
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CAS Number790663-33-1
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Formula Weight320.4
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Molecular FormulaC15H20N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (390.13 mM; Need ultrasonic)
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SMILESCOc1ccc(NC(=S)NCCCn2ccnc2)cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Huang K.-F Liaw S.-S Huang W.-Let al. Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding[J]. Journal of Biological Chemistry 286(14):12439-12449.
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