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ABT-724
CAS No. 70006-24-5
ABT-724( —— )
Catalog No. M21091 CAS No. 70006-24-5
ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 87 | In Stock |
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| 5MG | 78 | In Stock |
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| 25MG | 171 | In Stock |
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| 50MG | 251 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameABT-724
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NoteResearch use only, not for human use.
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Brief DescriptionABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
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DescriptionABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
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In VitroABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations.
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In VivoABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats. Animal Model:Male adult Wistar rats (~300 g) Dosage:8.8 μg/kg Administration:Subcutaneous injection; daily; for 5 daysResult:Dose-dependently facilitated penile erection.
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorD4
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Research Area——
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Indication——
Chemical Information
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CAS Number70006-24-5
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Formula Weight293.37
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Molecular FormulaC17H19N5
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Purity>98% (HPLC)
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Solubility——
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SMILESc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1
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Chemical Name1H-Benzimidazole 2-((4-(2-pyridinyl)-1-piperazinyl)methyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Brioni J D Moreland R B Cowart M et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats[J]. Proceedings of the National Academy of Sciences 2004 101(17):6758-6763.
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