Leucylarginylproline
CAS No. 133943-59-6
Leucylarginylproline( —— )
Catalog No. M21019 CAS No. 133943-59-6
Leucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 301 | In Stock |
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| 5MG | 325 | In Stock |
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| 10MG | 487 | In Stock |
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| 25MG | 724 | In Stock |
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| 50MG | 1051 | In Stock |
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| 100MG | 1423 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLeucylarginylproline
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NoteResearch use only, not for human use.
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Brief DescriptionLeucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).
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DescriptionLeucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).
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In VitroIntravenous injection of Leucylarginylproline (30mg/kg) causes a decrease in the blood pressure. The maximum mean blood pressure reduction (about 15 mmHg) occurrs about 2 min after the injection. Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetRAAS
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RecptorACE
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Research Area——
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Indication——
Chemical Information
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CAS Number133943-59-6
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Formula Weight384.47
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Molecular FormulaC17H32N6O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)CC(N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Alacepril
Alacepril is a relatively novel angiotensin-converting enzyme inhibitor used as an antihypertensive.
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N-Acetyl-Ser-Asp-Lys...
Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice.N-Acetyl-Ser-Asp-Lys-Pro (AcSDKP) is a specific substrate for the N-terminal site of ACE and increases 5-fold during ACE inhibitor therapy.??AcSDKP inhibited the proliferation of isolated cardiac fibroblasts (P<0.05) but significantly stimulated the proliferation of vascular smooth muscle cells.?
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Angiotensin IV
Angiotensin IV is a less effective agonist at the angiotensin AT1 receptor.
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