Adenosine amine congener

Research use only, not for human use.

Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.

Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.

Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways.

Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner. Animal Model:Male Wistar rats (8-10 weeks old) treated with noise exposure Dosage:25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day Administration:Intraperitoneal injection; daily; for 5 days Result:Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).

ADAC

Apoptosis

Adenosine Receptor

A1

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96760-69-9

576.6

C28H32N8O6

>98% (HPLC)

DMSO:31.25 mg/mL (54.20 mM)

NCCNC(=O)Cc1ccc(NC(=O)Cc2ccc(Nc3ncnc4c3ncn4C3OC(CO)C(O)C3O)cc2)cc1

——

(-20℃)

With Ice Pack

≥ 2 years