Gabazine

Research use only, not for human use.

Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).

Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).

Both bicuculline and Gabazine (SR 95531) have been characterized as competitive inhibitors of GABA binding to the GABAA receptor. Gabazine is more potent than bicuculline at blocking currents elicited by GABA, with an IC50 for currents elicited by 3 μM GABA of ~0.2 μM and a Hill coefficient of 1.0. Gabazine reduces the currents elicited by 10 μM alphaxalone by ~30%, for responses of receptors containing wildtype β2 subunits. The concentration of Gabazine requires producing half the maximal block is ~0.2 μM. Gabazine also could only produce a partial block of currents gated by 300 μM pentobarbital. The maximal reduction, again, is ~30%, and the concentration of Gabazine required to produce half the maximal block is ~0.15 μM.

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SR95531

Others

Other Targets

GABAA

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104104-50-9

368.23

C15H18BrN3O3

>98% (HPLC)

DMSO:75 mg/mL (203.68 mM)

Br.COc1ccc(-c2ccc(=N)n(CCCC(=O)O)n2)cc1

2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide

(-20℃)

With Ice Pack

≥ 2 years