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Ripasudil free base
CAS No. 223645-67-8
Ripasudil free base( K-115 (free base) )
Catalog No. M20890 CAS No. 223645-67-8
Ripasudil free base is a selective and potent ROCK inhibitor is a novel and potent antiglaucoma agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 146 | In Stock |
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| 10MG | 238 | In Stock |
|
| 25MG | 529 | In Stock |
|
| 50MG | 873 | In Stock |
|
| 100MG | 1460 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRipasudil free base
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NoteResearch use only, not for human use.
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Brief DescriptionRipasudil free base is a selective and potent ROCK inhibitor is a novel and potent antiglaucoma agent.
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DescriptionRipasudil free base is a selective and potent ROCK inhibitor is a novel and potent antiglaucoma agent.
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In VitroRipasudil (K-115) is a potent inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. Ripasudil also shows less potent inhibitory activities against CaMKIIα, PKACα and PKC, with IC50s of 370 nM, 2.1 μM and 27 μM, respectively. Ripasudil (K-115; 1, 10 μM) induces cytoskeletal changes, including retraction and cell rounding and reduced actin bundles of cultured trabecular meshwork (TM) cells. Ripasudil (5 μM) sifnificantly reduces transendothelial electrical resistance (TEER), and increases FITC-dextran permeability in Schlemm’s canal endothelial (SCE) cell monolayers.
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In VivoRipasudil (K-115) reduces intraocular pressure (IOP) in a concentration-dependent manner at concentrations between 0.1% and 0.4% in monkey eyes and 0.0625% to 0.5% in rabbit eyes, respectively. Ripasudil (K-115; 1 mg/kg, p.o. daily) shows a neuroprotective effect on retinal ganglion cells (RGCs) after nerve crush (NC). Ripasudil also inhibits the oxidative stress induced by axonal injury in mice. Ripasudil suppresses the time-dependent production of ROS in RGCs after NC injury.
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SynonymsK-115 (free base)
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research Area——
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Indication——
Chemical Information
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CAS Number223645-67-8
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Formula Weight323.39
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Molecular FormulaC15H18FN3O2S?
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Takatoshi U Megumi H Reiko Y et al. The Anti-Inflammatory Effect of Ripasudil (K-115) a Rho Kinase (ROCK) Inhibitor on Endotoxin-Induced Uveitis in Rats[J]. Investigative Opthalmology & Visual Science 2017 58(12):5584-.
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