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Ademetionine(b)
CAS No. 29908-03-0
Ademetionine(b)( S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet )
Catalog No. M20824 CAS No. 29908-03-0
Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 68 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 160 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAdemetionine(b)
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NoteResearch use only, not for human use.
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Brief DescriptionAdemetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
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DescriptionAdemetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
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In VitroApoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3%of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
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In VivoAnimal Model:Valproic acid treated young mice Dosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.
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SynonymsS-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaNeurological Disease
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IndicationMajor depressive disorder
Chemical Information
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CAS Number29908-03-0
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Formula Weight398.44
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Molecular FormulaC15H22N6O5S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (250.98 mM);H2O:43 mg/mL (107.92 mM)
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SMILESC[S+](CCC(N)C(=O)[O-])CC1OC(n2cnc3c(N)ncnc32)C(O)C1O
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Chemical Name(2S)-2-amino-4-((((2S3S4R5R)-5-(6-amino-9H-purin-9-yl)-34-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ivashkin V T Maevskaya M V Kobalava Z D et al. Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease.[J]. Minerva Gastroenterologica E Dietologica 2018.
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