Ademetionine(b)( S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet )

Catalog No. M20824 CAS No. 29908-03-0

Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ademetionine(b)
Note

Research use only, not for human use.
Brief Description

Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
Description

Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
In Vitro

Apoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3%of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
In Vivo

Animal Model:Valproic acid treated young mice Dosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.
Synonyms

S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Neurological Disease
Indication

Major depressive disorder

Chemical Information

CAS Number

29908-03-0
Formula Weight

398.44
Molecular Formula

C15H22N6O5S
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (250.98 mM);H2O:43 mg/mL (107.92 mM)
SMILES

C[S+](CCC(N)C(=O)[O-])CC1OC(n2cnc3c(N)ncnc32)C(O)C1O
Chemical Name

(2S)-2-amino-4-((((2S3S4R5R)-5-(6-amino-9H-purin-9-yl)-34-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ivashkin V T Maevskaya M V Kobalava Z D et al. Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease.[J]. Minerva Gastroenterologica E Dietologica 2018.

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