Belotecan hydrochloride

Research use only, not for human use.

Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity.

Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity.(In Vitro):Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.(In Vivo):Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.

Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.

Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.

CKD-602

Cell Cycle/DNA Damage

Topoisomerase

Topo I

Cancer

Non-small cell lung Cancer; Solid tumours

213819-48-8

469.96

C25H28ClN3O4

>98% (HPLC)

DMSO:50 mg/mL (106.39 mM)

CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CCNC(C)C.Cl

(4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]-ethyl]-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)dione hydrochloride

(-20℃)

With Ice Pack

≥ 2 years