Yoda 1( —— )

Catalog No. M20782 CAS No. 448947-81-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Yoda 1
Note

Research use only, not for human use.
Brief Description

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
Description

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
In Vitro

Western Blot Analysis Cell Line:human coronary artery endothelial cells (HCAECs), A431 cellsConcentration:0, 1.5, 3.0, and 6.0?μM Incubation Time:5 min Result:Induced the activation of both Akt and ERK1/2, and increased the phosphorylation levels of both Akt and ERK1/2 in a dose-dependent manner. Inhibited EGF-induced increase in the amount of Rac1-GTP, and inhibited Rac1 activation
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Piezo1
Research Area

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Indication

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1.Ruhma S Jie X Dubin A E et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife 2015 4.

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