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PZ-2891
CAS No. 2170608-82-7
PZ-2891( —— )
Catalog No. M20770 CAS No. 2170608-82-7
PZ-2891 is an orally bioavailable brain penetrant pantothenate kinase (PANK) modulator(hPANK3IC50:1.3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 343 | In Stock |
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| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePZ-2891
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NoteResearch use only, not for human use.
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Brief DescriptionPZ-2891 is an orally bioavailable brain penetrant pantothenate kinase (PANK) modulator(hPANK3IC50:1.3 nM).
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DescriptionPZ-2891 is an orally bioavailable brain penetrant pantothenate kinase (PANK) modulator(hPANK3IC50:1.3 nM).
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In VitroPZ-2891 inhibits mouse pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of48.7±5.1 nM, 1.0±0.1 nM, and 1.9±0.2 nM, respectively.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorpantothenate kinase (PANK)
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Research Area——
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Indication——
Chemical Information
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CAS Number2170608-82-7
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Formula Weight349.43
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Molecular FormulaC20H23N5O
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Purity>98% (HPLC)
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SolubilityDMSO:75 mg/mL (214.64 mM)
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SMILESCC(C)c1ccc(CC(=O)N2CCN(c3ccc(C#N)nn3)CC2)cc1
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Chemical Name6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lalit Kumar Sharma et al. A therapeutic approach to pantothenate kinase associated neurodegeneration.[J]. Nature communications 2018.
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