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DHBP dibromide
CAS No. 6159-05-3
DHBP dibromide( Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO )
Catalog No. M20752 CAS No. 6159-05-3
DHBP dibromide is calcium release and a muscle relaxant inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 43 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDHBP dibromide
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NoteResearch use only, not for human use.
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Brief DescriptionDHBP dibromide is calcium release and a muscle relaxant inhibitor.
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DescriptionDHBP dibromide is calcium release and a muscle relaxant inhibitor.
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In VitroDHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.
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In Vivo——
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SynonymsDiheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number6159-05-3
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Formula Weight514.38
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Molecular FormulaC24H38Br2N2
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Purity>98% (HPLC)
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SolubilityDMSO:30 mg/mL (58.32 mM)
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SMILES[Br-].[Br-].CCCCCCC[n+]1ccc(cc1)-c1cc[n+](CCCCCCC)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Aguilar-Sanchez Y Difranco M Darcy Y L et al. DHBP Reversibly Inhibits Calcium Release from Sarcoplasmic Reticulum (SR) in Skeletal Muscle and Heart[J]. Biophysical Journal 2017 112(3):161a-162a.
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