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Home - Products - Endocrinology/Hormones - RAAS - H-Val-Pro-Pro-OH

H-Val-Pro-Pro-OH

CAS No. 58872-39-2

H-Val-Pro-Pro-OH( —— )

Catalog No. M20748 CAS No. 58872-39-2

H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    H-Val-Pro-Pro-OH
  • Note
    Research use only, not for human use.
  • Brief Description
    H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).
  • Description
    H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).
  • In Vitro
    H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    ACE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    58872-39-2
  • Formula Weight
    311.38
  • Molecular Formula
    C15H25N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (40.14 mM)
  • SMILES
    CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Subhadeep C Forough J Davidge S T et al. Milk-derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Pre-adipocytes[J]. Journal of Agricultural and Food Chemistry 2018:acs.jafc.8b02051-.
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