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NP118809
CAS No. 41332-24-5
NP118809( 39-1B4 )
Catalog No. M20746 CAS No. 41332-24-5
NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 40 | In Stock |
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| 50MG | 53 | In Stock |
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| 100MG | 75 | In Stock |
|
| 200MG | 91 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNP118809
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NoteResearch use only, not for human use.
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Brief DescriptionNP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
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DescriptionNP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
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In VitroNP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM.
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In VivoNP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
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Synonyms39-1B4
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number41332-24-5
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Formula Weight460.61
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Molecular FormulaC32H32N2O
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (108.55 mM)
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SMILESO=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
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Chemical Name1-(4-benzhydrylpiperazin-1-yl)-33-diphenylpropan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zamponi G W Feng Z P Zhang L et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers[J]. Bioorganic & Medicinal Chemistry Letters 2009 19(22):6467-6472.
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