Cart
sales@molnova.com
NP118809
CAS No. 41332-24-5
NP118809( 39-1B4 )
Catalog No. M20746 CAS No. 41332-24-5
NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 10MG | 29 | In Stock |
|
| 25MG | 40 | In Stock |
|
| 50MG | 53 | In Stock |
|
| 100MG | 75 | In Stock |
|
| 200MG | 91 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNP118809
-
NoteResearch use only, not for human use.
-
Brief DescriptionNP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
-
DescriptionNP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
-
In VitroNP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM.
-
In VivoNP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
-
Synonyms39-1B4
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number41332-24-5
-
Formula Weight460.61
-
Molecular FormulaC32H32N2O
-
Purity>98% (HPLC)
-
SolubilityDMSO:50 mg/mL (108.55 mM)
-
SMILESO=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
-
Chemical Name1-(4-benzhydrylpiperazin-1-yl)-33-diphenylpropan-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Zamponi G W Feng Z P Zhang L et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers[J]. Bioorganic & Medicinal Chemistry Letters 2009 19(22):6467-6472.
molnova catalog
related products
-
A-1048400
A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
-
Ginsenoside-Rf
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
-
TPC2-A1-N
TPC2-A1-N is a novel lipophilic, membrane-permeable subtype-selective TPC2 small molecule agonist that activates endogenous TPC2 to moderately increase lysosomal pH in untransfected cells in a time-dependent manner, and can be used to assay the differential function of TPC2 channels in intact cells.
