Cart
sales@molnova.com
Valorphin
CAS No. 144313-54-2
Valorphin( Valorphin TFAsalt )
Catalog No. M20720 CAS No. 144313-54-2
Valorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
|
| 5MG | 93 | In Stock |
|
| 10MG | 139 | In Stock |
|
| 25MG | 277 | In Stock |
|
| 50MG | 418 | In Stock |
|
| 100MG | 626 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameValorphin
-
NoteResearch use only, not for human use.
-
Brief DescriptionValorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
-
DescriptionValorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
-
In VitroValorphin is a derivative of dihydrovaltrate with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM. Valorphin has low affinity for δ-opioid receptor (IC50, 200 nM) and shows no affinity for κ receptor (IC50, >10 μM). Valorphin (>10 μM) decreases spontaneous firing rate of cerebellar rat Purkinje cells. Valorphin (1 μM) treatment 48 h prior to 0.1 μM epirubicin, or 0.1 μM vincristine, or 0.05 μM vincristine, causes 100% tumor cell death.
-
In VivoValorphin exhibits pronounced analgesic activity in mice, rats and rhesus monkeys via s.c, with ED50s of ≤5.2 mg/kg, but barely active after oral administration. Valorphin (1 mg/kg) causes 42% of tumor growth inhibition in female BLRB mice bearing syngeneic mammary carcinoma cells.
-
SynonymsValorphin TFAsalt
-
PathwayEndocrinology/Hormones
-
TargetOpioid Receptor
-
RecptorOpioid Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number144313-54-2
-
Formula Weight893
-
Molecular FormulaC44H60N8O12
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Blishchenko E Y Sazonova O V Kalinina O A et al. Antitumor effect of valorphin in vitro and in vivo: Combined action with cytostatic drugs[J]. Cancer Biology & Therapy 2005 4(1):125-131.
molnova catalog
related products
-
PL 017
Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.
-
Propiram fumarate HC...
Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.
-
Spectinomycin dihydr...
Spectinomycin dihydrochloride pentahydrate is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
