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Home - Products - Chromatin/Epigenetic - Histone Demethylase - BRD9539

BRD9539

CAS No. 1374601-41-8

BRD9539( —— )

Catalog No. M20714 CAS No. 1374601-41-8

BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRD9539
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.
  • Description
    BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.
  • In Vitro
    BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    G9a
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1374601-41-8
  • Formula Weight
    399.44
  • Molecular Formula
    C24H21N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35 mg/mL (87.62 mM)
  • SMILES
    OC(=O)c1ccc2n(CCCc3ccccc3)c(NC(=O)c3ccccc3)nc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yuan Y Wang Q Paulk J et al. A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma[J]. ACS Chemical Biology 2012 7(7):1152-1157.
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