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Ralfinamide
CAS No. 133865-88-0
Ralfinamide( FCE-26742A | Priralfinamide )
Catalog No. M20711 CAS No. 133865-88-0
Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 31 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 59 | In Stock |
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| 50MG | 107 | In Stock |
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| 100MG | 164 | In Stock |
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| 200MG | 242 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRalfinamide
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NoteResearch use only, not for human use.
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Brief DescriptionRalfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
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DescriptionRalfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.(In Vivo):Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain.
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In Vitro——
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In VivoRalfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain. Animal Model:81 adult male Sprague–Dawley male rats (260–460 g)Dosage:80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)Administration:Oral gavage; twice daily; until postoperative day 42Result:Suppressed neuropathic pain.
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SynonymsFCE-26742A | Priralfinamide
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNa-channel
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Research AreaNeurological Disease
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IndicationNeuropathic pain
Chemical Information
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CAS Number133865-88-0
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Formula Weight302.34
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Molecular FormulaC17H19FN2O2
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (413.44 mM)
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SMILESC[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O
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Chemical Name(2S)-2-(4-(2-Fluorobenzyloxy)benzylamino)propanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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λ-Cyhalothrin
lambda-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group.lambda-Cyhalothrin is used to control a wide range of pests in a variety of applications.lambda-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system.
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APETx2
Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against acid-induced and inflammatory pain.
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PF-06305591
PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels.
