[Leu5]-Enkephalin

Research use only, not for human use.

[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM respectively).

[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM respectively).

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas.Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.

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Leu-enkephalin | Leucine enkephalin | Leucyl-enkephalin

Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

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58822-25-6

555.62

C28H37N5O7

>98% (HPLC)

DMSO:150 mg/mL (269.97 mM)

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O

L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucine

(-20℃)

With Ice Pack

≥ 2 years