Levomefolic Acid

CAS No. 31690-09-2

Levomefolic Acid( 5-MTHF )

Catalog No. M20673 CAS No. 31690-09-2

Levomefolinic acid is a natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Levomefolic Acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Levomefolinic acid is a natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency.
  • Description
    Levomefolinic acid is a natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency.(In Vitro):Levomefolic acid (5-MTHF) shows interaction with residues Glu406, Ile 418, Lys417 and Tyr453, of which Lys 417 and Tyr 453 play a strong physiological role in the interaction between S1 and ACE and may act as a potential inhibitor of the S1:ACE2 interaction of the SARS-CoV-2 virus.Levomefolic acid (5-MTHF) (50 nM, 72 h) increases intracellular folate metabolite activity by 7-fold better than folic acid by 2-fold in human lymphoblastoid cell line (LCL), and is a good folic acid supplement.
  • In Vitro
    Levomefolic acid (5-MTHF) shows interaction with residues Glu406, Ile 418, Lys417 and Tyr453, of which Lys 417 and Tyr 453 play a strong physiological role in the interaction between S1 and ACE and may act as a potential inhibitor of the S1:ACE2 interaction of the SARS-CoV-2 virus.Levomefolic acid (5-MTHF) (50 nM, 72 h) increases intracellular folate metabolite activity by 7-fold better than folic acid by 2-fold in human lymphoblastoid cell line (LCL), and is a good folic acid supplement.
  • In Vivo
    ——
  • Synonyms
    5-MTHF
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    31690-09-2
  • Formula Weight
    459.46
  • Molecular Formula
    C20H25N7O6
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:5 mg/mL (10.88 mM);DMSO:0.526 mg/mL (1.14 mM)
  • SMILES
    CN1[C@@H](CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12
  • Chemical Name
    (4-((((S)-2-amino-5-methyl-4-oxo-145678-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Thermal oxidation studies on reduced folate L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices.
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