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Benzamil (hydrochloride)

CAS No. 2898-76-2

Benzamil (hydrochloride)( —— )

Catalog No. M20570 CAS No. 2898-76-2

Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 69 In Stock
5MG 48 In Stock
10MG 57 In Stock
25MG 120 In Stock
50MG 222 In Stock
100MG 402 In Stock
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Biological Information

  • Product Name
    Benzamil (hydrochloride)
  • Note
    Research use only, not for human use.
  • Brief Description
    Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
  • Description
    Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
  • In Vitro
    Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels.
  • In Vivo
    Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    ENaC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2898-76-2
  • Formula Weight
    356.21
  • Molecular Formula
    C13H15Cl2N7O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1nc(N)c(nc1Cl)C(=O)NC(=N)NCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jeong S Lee S H Kim Y O et al. Antinociceptive Effects of Amiloride and Benzamil in Neuropathic Pain Model Rats[J]. Journal of Korean Medical Science 2013 28(8).
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