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H4 Receptor antagonist 1

CAS No. 848217-00-5

H4 Receptor antagonist 1( —— )

Catalog No. M20493 CAS No. 848217-00-5

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist with an IC50 of 19 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    H4 Receptor antagonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist with an IC50 of 19 nM.
  • Description
    H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist with an IC50 of 19 nM.
  • In Vitro
    H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
  • In Vivo
    H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    H4 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    848217-00-5
  • Formula Weight
    316.78
  • Molecular Formula
    C16H17ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mg/mL (31.57 mM)
  • SMILES
    CN1CCN(CC1)c1nc(C)nc2c3cc(Cl)ccc3oc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cramp S Dyke H J Higgs C et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists[J]. Bioorganic & Medicinal Chemistry Letters 2010 20(8):2516-2519.
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