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MS21570
CAS No. 65373-29-7
MS21570( —— )
Catalog No. M20480 CAS No. 65373-29-7
MS21570 as a GPR171 antagonist based on its ability to blockwith an IC50 of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 5MG | 36 | In Stock |
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| 10MG | 51 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 140 | In Stock |
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| 100MG | 209 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMS21570
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NoteResearch use only, not for human use.
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Brief DescriptionMS21570 as a GPR171 antagonist based on its ability to blockwith an IC50 of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.
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DescriptionMS21570 as a GPR171 antagonist based on its ability to blockwith an IC50 of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.
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In Vitro——
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In VivoMS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorGPR171
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Research Area——
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Indication——
Chemical Information
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CAS Number65373-29-7
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Formula Weight237.34
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Molecular FormulaC10H11N3S2
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (526.67 mM)
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SMILESCNc1nnc(SCc2ccccc2)s1
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Chemical Name5-(benzylthio)-N-methyl-134-thiadiazol-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bobeck E N Gomes I Pena D et al. The BigLEN-GPR171 Peptide Receptor System within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning[J]. Neuropsychopharmacology 2017.
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