HYOSCINE HYDROCHLORIDE

Research use only, not for human use.

HYOSCINE HYDROCHLORIDE versus placebo in preventing motion sickness has been shown to be effective.

HYOSCINE HYDROCHLORIDE versus placebo in preventing motion sickness has been shown to be effective.

Scopolamine blocks nicotinic acetylcholine receptors (IC50=928 μM) and increases the expression of α7 nACh receptors. Scopolamine displays concentration-dependent competition with 0.6 nM [3H]Granisetron, yielding an average pKi of 5.17±0.24 (Ki=6.76 μM). Concentration-dependent competition of fluorescently labeled form of granisetron (G-FL) with Scopolamine gives an average pKi of 5.31±0.09 (Ki=4.90 μM).Scopolamine blocks muscarinic receptors and induces a cognitive deficit.Scopolamine (0.1-3 mM; for 24 hours) induces cytotoxicity, ROS generation and apoptosis of SH-SY5Y cells.Cell Viability Assay Cell Line:Human neuroblastoma SH-SY5Y cell line Concentration:0.1-3 mM (usually 2 mM) Incubation Time:24 hours Result:Exposure to 1-3 mM for 24 hours significantly decreased human neuroblastoma SH-SY5Y cell viability in a dose-dependent manner. In all subsequent experiments, 2 M resulted in 50.6±2.2% loss in cell viability.

Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain. Animal Model:Naive male Swiss mice weighing 20-25 Dosage:1mg/kg Administration: Administered intraperitoneally (i.p.); to measure the memory acquisition processes, Scopolamine was administered 20 min before the pretest; to measure the memory consolidation processes, Scopolamine was administered immediately after the pretest Result:In scopolamine-treated group, there was a significant decrease in the index of latency (IL) value as compared with the saline-treated mice, indicating that scopolamine at the used dose impaired acquisition of memory and learning.

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Others

Other Targets

Others

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55-16-3

339.8

C17H22ClNO4?

>98% (HPLC)

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Cl.[H][C@@]12O[C@]1([H])[C@H]1C[C@H](C[C@@H]2N1C)OC(=O)[C@H](CO)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years