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Stachydrine
CAS No. 471-87-4
Stachydrine( Proline betaine | L-stachydrine | Methyl hygrate betaine | NN-Dimethyl-L-proline )
Catalog No. M20448 CAS No. 471-87-4
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 71 | In Stock |
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| 50MG | 94 | In Stock |
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| 100MG | 130 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameStachydrine
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NoteResearch use only, not for human use.
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Brief DescriptionStachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.
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DescriptionStachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.
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In VitroStachydrine can inhibit the NF-κB signal pathway, and this may be related to the mechanism of anti-hypertrophic. Intervention of stachydrine significantly suppresses the level of p-IκB protein in the cytosol and NF-κB protein in the nucleus . Tissue factor mRNA is decreased in stachydrine-treated human umbilical vein endothelial cells. Stachydrine attenuates the decline of human umbilical vein endothelial cells viability and the increase of LDH activity induced by anoxia-reoxygenation. A dose dependent decrease in expression of mRNA, and protein levels are observed in stachydrine-treated human prostate cancer cells (PC-3 and LNcaP).
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In VivoStachydrine attenuates norepinephrine-induced cardiomyocyte hypertrophy and has potential protective effects against β-adrenergic receptor induced Ca2+ mishandling. Stachydrine treatment reduces the expressions of PERK, CHOP, and caspase-3 in the endoplasmic reticulum stress-related apoptosis pathway.
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SynonymsProline betaine | L-stachydrine | Methyl hygrate betaine | NN-Dimethyl-L-proline
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PathwayApoptosis
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TargetNF-κB
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Recptorp65
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Research Area——
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Indication——
Chemical Information
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CAS Number471-87-4
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Formula Weight143.18
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Molecular FormulaC7H13NO2
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Purity>98% (HPLC)
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SolubilityDMSO:26 mg/mL (181.59 mM);H2O:32 mg/mL (223.49 mM)
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SMILESC[N+]1(C)CCC[C@H]1C([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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