zerumbone

Research use only, not for human use.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities contributing to immunomodulatory and hepatoprotective effects.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities contributing to immunomodulatory and hepatoprotective effects.

Cell Proliferation Assay Cell Line:HeLa, Coav-3, and MCF-7 Concentration:20.3 μM for HeLa, 24.3 μM for Coav-3, 27.7 μM for MCF-7 Incubation Time:72 h Result:Showed IC50 values of 20.30 ± 1.1, 24.30 ± 0.9 and 27.7 ± 1.2 μM for HeLa, Coav-3, and MCF-7.Apoptosis Analysis Cell Line:HeLa Concentration:20.3 μM Incubation Time:72 h Result:Significantly stimulated caspase-3.Triggered morphological features that relates to apoptosis in a time-dependent manner.

Animal Model:Carrageenan (HY-125474)-induced mice paw edema/Cotton pellet-induced granuloma mice Dosage:5 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg Administration:Intraperitoneal injection (i.p.)Result: Significantly produced dose-dependent inhibition of paw oedema induced by carrageenan in mice with inhibition of 33.3, 66.7, 83.3, and 83.3%, respectively.Produced a significant reduction on the granulomatous tissue formation on implanted cotton pellets with inhibition of 34.8, 60.6 and 70.6%, respectively.

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Others

Other Targets

Others

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471-05-6

218.33

C15H22O

>98% (HPLC)

DMSO:44 mg/mL (201.53 mM)

C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1

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(-20℃)

With Ice Pack

≥ 2 years