Dimethyl malonate( —— )

Catalog No. M20375 CAS No. 108-59-8

Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	44	In Stock
100MG	Get Quote	In Stock
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500MG	39	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Dimethyl malonate
Note

Research use only, not for human use.
Brief Description

Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.
Description

Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.
In Vitro

——
In Vivo

Animal Model:Sprague-Dawley male rats, cardiac arrest modelDosage:6 mg/kg/minAdministration:Intravenous infusion, 51 minResult:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Succinate Dehydrogenase
Research Area

——
Indication

——

Chemical Information

CAS Number

108-59-8
Formula Weight

132.11
Molecular Formula

C5H8O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (756.94 mM)
SMILES

COC(=O)CC(=O)OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Xu J Pan H Xie X et .al.Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest[J].Neuroscience. 2018 Nov 21;393:24-32

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