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AHR antagonist 1

CAS No. 2162982-11-6

AHR antagonist 1( —— )

Catalog No. M20332 CAS No. 2162982-11-6

AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist has an IC50 of 39.9 nM in human cell line.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 68 In Stock
2MG 44 In Stock
5MG 63 In Stock
10MG 111 In Stock
25MG 250 In Stock
50MG 415 In Stock
100MG 617 In Stock
200MG Get Quote In Stock
500MG 1293 In Stock
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Biological Information

  • Product Name
    AHR antagonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist has an IC50 of 39.9 nM in human cell line.
  • Description
    AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist has an IC50 of 39.9 nM in human cell line.
  • In Vitro
    RT-PCR Cell Line:human monocytic U937 cells Concentration:1 nM-3 μM Incubation Time:Result:Regulated antagonise ligand-induced AHR gene in a dose-dependent manner.
  • In Vivo
    Animal Model:Balb/c mice (subcutaneously CT26 cells) Dosage:30 mg/kg Administration:p.o, bid Result:Significantly decreased tumors size combinated with aPD-L1.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2162982-11-6
  • Formula Weight
    401.82
  • Molecular Formula
    C20H17ClFN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (622.17 mM)
  • SMILES
    C[C@@H](CO)NC(=O)c1cc(nn(-c2cccc(F)c2)c1=O)-c1ccc(Cl)cc1
  • Chemical Name
    (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-23-dihydropyridazine-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ilona Gutcher Christina Kober Lars Roeseet al.Abstract 1288: Blocking tumor-associated immune suppression with BAY-218 a novel selective aryl hydrocarbon receptor (AhR) inhibitor[J].10.1158/1538-7445.AM2019-1288 Published July 2019.
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