Fosphenytoin sodium

Research use only, not for human use.

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker.

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker.(In Vivo):Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).

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Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).

ACC-9653

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

Neuropathic pain

92134-98-0

406.24

C16H13N2Na2O6P

>98% (HPLC)

H2O:100 mg/mL (246.16 mM)

[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years