Bivalirudin( Hirulog-1 | BG-8967 )

Catalog No. M20244 CAS No. 128270-60-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Bivalirudin
Note

Research use only, not for human use.
Brief Description

Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM respectively) enzymes that exhibit high fibrinogen-clotting activities.
Description

Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM respectively) enzymes that exhibit high fibrinogen-clotting activities.(In Vivo):Bivalirudin (2 mg/kg) delays both the time for appearance of first thrombus and the time for occlusion in P2Y12+/+ arteries, although neither prevented vessel occlusion.
In Vitro

——
In Vivo

Bivalirudin (2 mg/kg) delays both the time for appearance of first thrombus and the time for occlusion in P2Y12+/+?arteries, although neither prevented vessel occlusion.
Synonyms

Hirulog-1 | BG-8967
Pathway

Autophagy
Target

Thrombin
Recptor

Thrombin
Research Area

Cardiovascular Disease
Indication

heparin-induced thrombocytopenia

CAS Number

128270-60-0
Formula Weight

2180.29
Molecular Formula

C98H138N24O33
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 10 mg/mL (4.59 mM)
SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(O)=O
Chemical Name

——

1.Witting JI et al. Thrombin-specific inhibition by and slow cleavage of hirulog-1. Biochem J. 1992 May 1;283 ( Pt 3):737-43.

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