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Tyrosine kinase-IN-1
CAS No. 705946-27-6
Tyrosine kinase-IN-1( —— )
Catalog No. M20206 CAS No. 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
|
| 2MG | 35 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 93 | In Stock |
|
| 25MG | 187 | In Stock |
|
| 50MG | 276 | In Stock |
|
| 100MG | 398 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTyrosine kinase-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionTyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively).
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DescriptionTyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively）.
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In VitroTyrosine kinase-IN-1 is from reference (compound 8K).
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In VivoTyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats.
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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RecptorKDR|Flt-1|FGFR1|PDGFRα|PDGFRα
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Research Area——
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Indication——
Chemical Information
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CAS Number705946-27-6
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Formula Weight445.54
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Molecular FormulaC26H28FN5O
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL (160.47 mM)
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SMILESCCN1CCC(CC1)Nc1ccc2NC(=O)\C(=C(/c3ncc(C)[nH]3)c3cccc(F)c3)c2c1
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Chemical Name(Z)-5-((1-ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Moon K et al. The design synthesis and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985
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