Pyronaridine

Research use only, not for human use.

Pyronaridine also known as Malaridine is an antimalarial drug.It inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC50 value of approximately 10 nM.

Pyronaridine also known as Malaridine is an antimalarial drug.It inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC50 value of approximately 10 nM

Pyronaridine (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM.

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice.Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice.Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice. Animal Model: Echinococcus granulosus-infected mice modelDosage:57 mg/kg Administration:Oral administration, q.d. for 30 days Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.

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Others

Other Targets

Others

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74847-35-1

518

C29H32ClN5O2

>98% (HPLC)

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COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1

2-Methoxy-7-chloro-10-(3'5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-15-naphthyridine

(-20℃)

With Ice Pack

≥ 2 years