A-381393( —— )

Catalog No. M20141 CAS No. 726174-00-1

A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	76	In Stock
5MG	69	In Stock
10MG	113	In Stock
25MG	210	In Stock
50MG	297	In Stock
100MG	429	In Stock
200MG	603	In Stock
500MG	Get Quote	In Stock
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Biological Information

Product Name

A-381393
Note

Research use only, not for human use.
Brief Description

A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
Description

A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
In Vitro

A-381393 exhibits weak affinity at 5-HT1A, Sigma 2, Adenoceptor α1A, Adenoceptor α2C, Histamine H1, with Kis of 1365, 8600, 2044, 1912 and 2962 nM, respectively.
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

D4
Research Area

——
Indication

——

Chemical Information

CAS Number

726174-00-1
Formula Weight

320.43
Molecular Formula

C20H24N4
Purity

>98% (HPLC)
Solubility

DMSO: 50 mg/mL (156.04 mM)
SMILES

Cc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1
Chemical Name

2-[[4-(34-dimethylphenyl)piperazin-1-yl]methyl]-1H-benzimidazole

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Nakane M et al. 2-[4-(34-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21.

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