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L-BUTHIONINE-(SR)-SULFOXIMINE

CAS No. 83730-53-4

L-BUTHIONINE-(SR)-SULFOXIMINE( L-Butionine sulfoximine )

Catalog No. M20128 CAS No. 83730-53-4

L-Buthionine-(SR)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-BUTHIONINE-(SR)-SULFOXIMINE
  • Note
    Research use only, not for human use.
  • Brief Description
    L-Buthionine-(SR)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.
  • Description
    L-Buthionine-(SR)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6J pun/pun mice.Dosage:2 mM L-Buthionine-(S,R)-sulfoximine (BSO), 20 mM BSO, 2 mM BSO and 20 mM NAC, 20 mM NAC or unsupplemented water for 18 days from 0.5 to 18.5 d.p.c. The pH of supplemented water is as follows: 6.88, 20 mM BSO; 3.37, 2 mM BSO; 2.65, 2 mM BSO plus 20 mM NAC; and 2.58, 20 mM NAC. The pH of regular water used in our facility is ~4. Administration:Drinking water.Result:The average number of eye-spots (mean±SEM) is 5.36±0.29 (n=46), 7.79±0.45 (n=34) and 8.78±0.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively. The 2 mM BSO treatment results in ~30% more eye-spots, and the 20 mM treatment results in 40% more eye-spots compared with untreated mice.
  • Synonyms
    L-Butionine sulfoximine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    γ-glutamylcysteine synthetase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    83730-53-4
  • Formula Weight
    222.31
  • Molecular Formula
    C8H18N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:41.67 mg/mL (187.44 mM; Need ultrasonic)
  • SMILES
    CCCCS(=N)(=O)CC[C@H](N)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fruehauf JP et al. Selective and synergistic activity of L-SR-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49.
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