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Home - Products - Membrane Transporter/Ion Channel - Monocarboxylate Transporter - BAY8002

BAY8002

CAS No. 724440-27-1

BAY8002( BAY 8002 | BAY-8002 )

Catalog No. M20102 CAS No. 724440-27-1

BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3 8 and 12 nM at rat (C6) human (DLD-1) and mouse (4T1) MCT1 respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BAY8002
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3 8 and 12 nM at rat (C6) human (DLD-1) and mouse (4T1) MCT1 respectively).
  • Description
    BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3 8 and 12 nM at rat (C6) human (DLD-1) and mouse (4T1) MCT1 respectively).
  • In Vitro
    BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 μM in EVSA-T cells).
  • In Vivo
    BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice. Animal Model:Female NOD SCID mice bearing Raji cells (7-10 weeks old) Dosage:80 and 160 mg/kg Administration:P.O. twice daily for more than 26 days Result:Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression.
  • Synonyms
    BAY 8002 | BAY-8002
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Monocarboxylate Transporter
  • Recptor
    MCT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    724440-27-1
  • Formula Weight
    415.85
  • Molecular Formula
    C20H14ClNO5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 50 mg/mL (120.24 mM)
  • SMILES
    OC(=O)c1ccccc1NC(=O)c1cc(ccc1Cl)S(=O)(=O)c1ccccc1
  • Chemical Name
    2-(2-chloro-5-(phenylsulfonyl)benzamido)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Quanz M et al. Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. Mol Cancer Ther. 2018 Nov;17(11):2285-2296.
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