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N-Acetylglutamic acid

CAS No. 1188-37-0

N-Acetylglutamic acid( Ac-L-Glu-OH )

Catalog No. M19990 CAS No. 1188-37-0

N-Acetyl-L-glutamic acid (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    N-Acetylglutamic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    N-Acetyl-L-glutamic acid (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS).
  • Description
    N-Acetyl-L-glutamic acid (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS). NAcGlu activates carbamoyl phosphate synthetase in the urea cycle. A deficiency in N-acetyl glutamate synthase or a genetic mutation in the gene coding for the enzyme will lead to urea cycle failure in which ammonia is not converted to urea but rather accumulated in the blood leading to the condition called Type I hyperammonemia.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ac-L-Glu-OH
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1188-37-0
  • Formula Weight
    189.17
  • Molecular Formula
    C7H11NO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:200 mM
  • SMILES
    CC(=O)N[C@@H](CCC(O)=O)C(O)=O
  • Chemical Name
    acetyl-L-glutamic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tavazzi B et al. Simultaneous high performance liquid chromatographic separation of purines pyrimidines N-acetylated amino acids and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Clin Biochem. 2005 Nov;38(11):997-1008.
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