Procyclidine hydrochloride

Research use only, not for human use.

Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.

Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.(In Vivo):Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) hydrochloride in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether.

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Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) hydrochloride in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether. Animal Model:Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs Dosage:0.3-6.0 mg/kg Administration:Subcutaneous injection; once Result:Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.

(±)-Procyclidine hydrochlorid

Membrane Transporter/Ion Channel

NMDAR

NMDA receptor

Neurological Disease

Parkinson's disease

1508-76-5

323.9

C19H30ClNO

>98% (HPLC)

DMSO: 10 mg/mL

Cl.OC(CCN1CCCC1)(C1CCCCC1)c1ccccc1

1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years