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Propiverine hydrochloride
CAS No. 54556-98-8
Propiverine hydrochloride( —— )
Catalog No. M19811 CAS No. 54556-98-8
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 35 | In Stock |
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| 50MG | 50 | In Stock |
|
| 100MG | 72 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePropiverine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPropiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).
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DescriptionPropiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).(In Vitro):Propiverine (10-3000 nM) inhibits the speci c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.(In Vivo):Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo.
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In VitroPropiverine (10-3000 nM) inhibits the speci?c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.
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In VivoPropiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo. Animal Model:Female adult Sprague-Dawley rats (250-270 g)Dosage:5 mg dissolved in distilled water (0.5 mL)Administration: P.o. once daily for 2 weeks Result:Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.Increased plasma epinephrine and norepinephrine levels.No significant changes were observed in body weight.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaNeurological Disease
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IndicationOveractive bladder; Urinary incontinence
Chemical Information
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CAS Number54556-98-8
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Formula Weight403.94
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Molecular FormulaC23H30ClNO3
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Purity>98% (HPLC)
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SolubilityDMSO:198 mM
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SMILESCl.CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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