Medroxyprogesterone( —— )

Catalog No. M19809 CAS No. 520-85-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Medroxyprogesterone
Note

Research use only, not for human use.
Brief Description

Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
Description

Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
In Vitro

Cell Proliferation Assay Cell Line:T47D Concentration:10 nM Incubation Time:24 h, 48 h, 72h Result:Increased the number of cells at 48 h.Western Blot Analysis Cell Line:T47D Concentration:10 nM Incubation Time:4 h Result:Induced the expression of Cyclin D1 protein.RT-PCR Cell Line:HUVECs Concentration:100 nM Incubation Time:24 h Result:Increased mRNA and protein expression of adhesion molecules.
In Vivo

Animal Model:ApoE-/- mice model Dosage:27.7 μg/day Administration:s.c.Result:Reduced atherosclerotic plaque and increased thrombosis.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen/progestogen Receptor
Research Area

Inflammation/Immunology
Indication

Autoimmune haemolytic anaemia; Crohn's disease; Idiopathic thrombocytopenic purpura; Ulcerative colitis

CAS Number

520-85-4
Formula Weight

344.49
Molecular Formula

C22H32O3
Purity

>98% (HPLC)
Solubility

DMSO:197.4 mM
SMILES

C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Chemical Name

Pregn-4-ene-320-dione 17-hydroxy-6-alpha-methyl-

1.Okojie A K Oyekunle O A . Depo-Provera effects on Wistar rat performance in the Y-maze.[J]. Metabolic Brain Disease 2014 29(2):529-31.

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