Loureirin A
CAS No. 119425-89-7
Loureirin A( —— )
Catalog No. M19777 CAS No. 119425-89-7
Loureirin A has an inhibitory effect on platelet activation perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen collagen-related peptide (CRP) ADP and thrombin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 207 | In Stock |
|
| 5MG | 128 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 330 | In Stock |
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| 50MG | 479 | In Stock |
|
| 100MG | 682 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLoureirin A
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NoteResearch use only, not for human use.
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Brief DescriptionLoureirin A has an inhibitory effect on platelet activation perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen collagen-related peptide (CRP) ADP and thrombin.
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DescriptionLoureirin A has an inhibitory effect on platelet activation perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen collagen-related peptide (CRP) ADP and thrombin. Loureirin A activates Wnt/-catenin pathway and promotes hair follicle stem cells (FSCs)-seeded tissue-engineered skin to repair skin wound.The molecular mechanism of Loureirin A and Wnt signaling pathway mediated anti- hepatic fibrosis and anti- angiogenesis may involve down- regulation the expression of Frizzled- 4inhibiting the synthesis and secretion of α- SMATGF- β1and the proliferation of HSCs.
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In VitroLoureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number119425-89-7
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Formula Weight286.32
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Molecular FormulaC17H18O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 86.6 mg/mL (302.46 mM)
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SMILESCOc1ccc(CCC(=O)c2ccc(O)cc2)c(OC)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hao H Z He A D Wang D C et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies[J]. European Journal of Pharmacology 2015 746:63-69.
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