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3-Methoxytyramine hydrochloride
CAS No. 1477-68-5
3-Methoxytyramine hydrochloride( 3-O-methyl Dopamine hydrochloride | 3-O-methyl Dopamine hydrochloride) )
Catalog No. M19566 CAS No. 1477-68-5
3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 50MG | 27 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name3-Methoxytyramine hydrochloride
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NoteResearch use only, not for human use.
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Brief Description3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
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Description3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be found primarily in human brain and most tissues tissues; and in blood cerebrospinal fluid (csf) or urine. Within a cell 3-methoxytyramine is primarily located in the cytoplasm.
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In VitroThe intensity of the fluorescence developed is in a linear relation to the amount of 3-Methoxytyramine hydrochloride presented in the sample up to at least 1 μg. When a high concentration of dopamine is present in the reaction mixture, there is some reduction in the fluorescence derived from3-Methoxytyramine hydrochloride.
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In VivoThe extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity however, is mostly presented as a set of disorganized abnormal movements that includes tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 μg, at 9 μg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 μg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 μg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs.
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Synonyms3-O-methyl Dopamine hydrochloride | 3-O-methyl Dopamine hydrochloride)
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PathwayOthers
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TargetOther Targets
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RecptorTAAR1
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Research Area——
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Indication——
Chemical Information
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CAS Number1477-68-5
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Formula Weight203.67
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Molecular FormulaC9H14ClNO2
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL;Water: 50 mg/mL
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SMILESCl.COc1cc(CCN)ccc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sotnikova TD et al. The dopamine metabolite 3-methoxytyramine is a neuromodulator. PLoS One. 2010 Oct 18;5(10):e13452.
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