DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.DS-6051b inhibited the growth of the ROS1 fusion-positive HCC78 cancer cell line and the CD74-ROS1 overexpressed Ba/F3 cells.

8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,In vitro, aggregates of buccal epithelial cells were irradiated and cultured in suspension for 11 days.

The flavonoid component of Nepalese and Sino-Japanese crude drugs.1,2 Baicalein,a major flavone of Scutellariae baicalensis,inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism,which inhibits Y cell proliferation and induce.