Cletoquine( 2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl]amino]ethanol | (±)-Desethylhydroxychloroquine | Desethylhydroxychloroquine )

Catalog No. M19380 CAS No. 4298-15-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Cletoquine
Note

Research use only, not for human use.
Brief Description

Cletoquine is a metabolite of Hydroxychloroquine (H916900) an antimalarial; antirheumatic; lupus erythematosus suppressant.
Description

Cletoquine is a metabolite of Hydroxychloroquine (H916900) an antimalarial; antirheumatic; lupus erythematosus suppressant.
In Vitro

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In Vivo

Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5).
Synonyms

2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl]amino]ethanol | (±)-Desethylhydroxychloroquine | Desethylhydroxychloroquine
Pathway

Microbiology/Virology
Target

Antifection
Recptor

Influenza Virus
Research Area

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Indication

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1.Gahl W. et al.: Mol. Genet. Metab. 76 234 (2002); Card J. et al.: Toxicol. Sci. 75 169 (2003)

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