Tenuifoliside A( —— )

Catalog No. M19344 CAS No. 139726-35-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tenuifoliside A
Note

Research use only, not for human use.
Brief Description

Tenuifoliside A has anti-apoptotic, neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.
Description

Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.
In Vitro

Tenuifoliside A (6-30 μM; 24 hours) increases the C6 cells viabilitysignificantly by concentration dependent manner. But the viability of the 60 μM treatment group is suppressed. Only 60 μM TFSA induced the release of LDH, shows a toxic effect.Tenuifoliside A (10 μM; 2, 5, 7, 10, 15, 30, 45 and 60 mins) elicits a rapid (starting at 2 min) and marked induction of ERK1/2 phosphorylation peaking at 5 min. And,the enhanced levels of phospho-ERK induced by TFSA are partially blocked by ERK inhibitor U0126.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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CAS Number

139726-35-5
Formula Weight

682.6
Molecular Formula

C31H38O17
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (146.49 mM)
SMILES

COc1cc(cc(OC)c1OC)/C=C/C(=O)OC[C@H]4O[C@H](O[C@@]3(CO)O[C@@H](CO)[C@H](O)[C@H]3OC(=O)c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]4O
Chemical Name

——

1. Kim KS., et al. Eur J Pharmacol.2013 Dec 5;721(1-3):267-76.

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