Cart
sales@molnova.com
AZ32
CAS No. ——
AZ32( —— )
Catalog No. M19313 CAS No. ——
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | Get Quote |
|
| 10MG | 191 | Get Quote |
|
| 25MG | 467 | Get Quote |
|
| 50MG | 719 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAZ32
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
-
DescriptionAZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
TargetERK
-
RecptorATM|ATM (in cell)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight328.37
-
Molecular FormulaC20H16N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCNC(=O)c1ccc(cc1)c2cnc3cnc(cn23)c4ccccc4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647.
molnova catalog
related products
-
BIX02188 (c)
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM.
-
SMI-4a
TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
-
DEL-22379
A small molecule inhibitor of ERK dimerization with IC50 of 0.5 uM, without affecting ERK phosphorylation.
