Isatin

Research use only, not for human use.

Isatin is an endogenous MAO inhibitor.

Isatin, also called Tribulin, is a MAO-B and guanylate cyclase inhibitor found in Istasis, Calanthe and Courouptia. It prevents TNBS-induced increases in pro-inflammatory cytokines and protects agains colitis-induced injuries. Derivatives may inhibit cancer cell growth.(In Vitro):In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis.(In Vivo):A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations.

In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis.

A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations.

Isatin | 2,3-Dioxo-2,3-dihydroindole | Isatic acid lactam | Isotin

Others

Antioxidant

MAO

Neurological Disease

——

91-56-5

147.13

C8H5NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (679.67 mM)

C1=CC=C2C(=C1)C(=O)C(=O)N2

indoline-2,3-dione

(-20℃)

With Ice Pack

≥ 2 years