K 0859( NVP-BGG463 )

Catalog No. M19234 CAS No. 890129-26-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

K 0859
Note

Research use only, not for human use.
Brief Description

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
Description

NVP-BGG463 is a novel Type II kinase inhibitor, targeting CDK2.
In Vitro

BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.
In Vivo

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Synonyms

NVP-BGG463
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

c-ABL-T334I|Abl|Abl (T315I)
Research Area

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Indication

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CAS Number

890129-26-7
Formula Weight

578.6
Molecular Formula

C30H29F3N6O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL; 216.05 mM
SMILES

CC(=O)Nc1cc(ncn1)Oc2ccc3c(c2)cccc3C(=O)Nc5ccc(CN4CCN(C)CC4)c(c5)C(F)(F)F
Chemical Name

6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide