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K 0859
CAS No. 890129-26-7
K 0859( NVP-BGG463 )
Catalog No. M19234 CAS No. 890129-26-7
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 148 | In Stock |
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| 2MG | 75 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 351 | In Stock |
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| 50MG | 494 | In Stock |
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| 100MG | 714 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameK 0859
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NoteResearch use only, not for human use.
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Brief DescriptionBGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
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DescriptionNVP-BGG463 is a novel Type II kinase inhibitor, targeting CDK2.
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In VitroBGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.
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In Vivo——
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SynonymsNVP-BGG463
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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Recptorc-ABL-T334I|Abl|Abl (T315I)
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Research Area——
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Indication——
Chemical Information
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CAS Number890129-26-7
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Formula Weight578.6
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Molecular FormulaC30H29F3N6O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 125 mg/mL; 216.05 mM
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SMILESCC(=O)Nc1cc(ncn1)Oc2ccc3c(c2)cccc3C(=O)Nc5ccc(CN4CCN(C)CC4)c(c5)C(F)(F)F
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Chemical Name6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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