L-Sophoridine

Research use only, not for human use.

Sophoridine, a natural product obtained from medicinal plants, which has a variety of pharmacological effects.

Sophoridine, a natural product obtained from medicinal plants, which has a variety of pharmacological effects, including anti-Y effects, and selectively induces apoptotic cell death in a variety of human Y cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated.

Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM.Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively. Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.

Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors.

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Others

Other Targets

Others

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83148-91-8

248.36

C15H24N2O

>98% (HPLC)

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N12CCC[C@@H]3[C@@H]4N(C[C@H]([C@H]13)CCC2)C(=O)CCC4

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(-20℃)

With Ice Pack

≥ 2 years